The Aebi Lab - Microbial Glycobiology
Our laboratory is interested in various aspects of glycobiology in prokaryotic and eukaryotic microorganisms. We use microbial model systems to study mechanistic and functional aspects of glycans.
Having contributed to the dissection of the eukaryotic pathway of N-linked protein glycosylation in the yeast Saccharomyces cerevisiae, the laboratory continues to work on the molecular mechanism of N-linked protein glycosylation in bacterial (classical and non-classical) and eukaryotic cells as well as the processing of N-linked glycans in the ER and the Golgi.
All prokaryotic and eukaryotic cells are coated with glycans, many of them covalently linked to proteins or lipids. Glycans therefore play a crucial role in the interaction between cells and their environment. In our laboratory, we study the role of glycans and glycan-binding proteins (lectins) in the interaction of fungi with competitors, predators and parasites including microbes and animals.