Institute of Microbiology

The Hardt Lab - Salmonella Pathogenesis

Research Projects

  • Background  »»
  • The process of TTSS-1 effector protein translocation into host
    cells  »»
  • Manipulation of host cell signal transduction by TTSS-1 effector
    proteins  »»
  • Murine model for studying Salmonella Typhimurium
    enterocolitis in vivo »»
  • The role of the gut flora in enteric infections »»


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Other Links

  • ETH Research DB  »»
  • Life Sciences Zurich  »»
  • PubMed Listing  »»
  • Teaching program  »»

Research funding

  • EU  »»
  • ETH  »»
  • SNF  »»
  • Vontobel-Stiftung »»
  • UBS Promedica Stiftung
  • Novartis Research Foundation »»
  • The Bill & Melinda Gates Foundation »»
  • KTI »»

We analyze the molecular mechanisms of Salmonella enterocolitis. The SPI-1 Type III secretion system of Salmonella Typhimurium (TTSS-1) is of special interest.

Salmonella spp. are pathogenic bacteria which can colonize the intestine of humans and animals. They belong to the most common causes of intestinal infection world wide. Diarrhea results from a complex network of interactions between the pathogenic bacterium, the intestinal epithelium, the commensals, and the immune system of the host. The S. Typhimurium virulence factors (i.e. TTSS-1) steer these interactions. The TTSS-1 works like a nano-scale syringe and allows S. Typhimurium injecting bacterial proteins (called effector proteins) into cells of the host’s intestine and manipulating communication within the affected cells. We want to find out how this can trigger inflammation. This may lead the way to new strategies for cure and prevention.

Research projects

Figure: Working model: role of the Salmonella Typhimurium TTSS-1 in the induction of enterocolitis.


[movie small - 9 MB] [movie medium - 32 MB] [movie large - 67 MB]


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